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When Syedna Yusouf Najmuddin ascended onto the throne of Dawat, Mughal emperor Humayu had conquered Gujarat defeating Bahadur Shah, the grandson of Mahmud Shah. After some time, emperor Humayu lost his empire to an Afghan rebel called Sher shah Suri. During this hard and difficult time, when Humayu was passing through Mewar in order to get support of Rajputs against Sher Shah, Moomineen helped him greatly. They received him as a guest, hosted him with honour, and led him to find safe ways during his journey. The emperor was so pleased and grateful to Moomineen that in obligation he granted them a Farman (a Royal decree). The Farman written by Bayram Khan declares - 
 
'This Farman (Royal Decree) of freedom of trade is written in the state of Hind for 'Bohras, Shia, Ismailiah sect.
When the emperor of Hind had to journey to the far flung areas of Marwari desert due to the difficulties of the time, most of the people showed disloyalty to the emperor. But, during this hard journey, when a group of Bohra traders heard about the presence of the emperor in the area, they came to him, hosted him and his troop heartily, and led them to show the safe ways to the border of Hindustan. Therefore, according to the order of the emperor, this farman for the freedom of trade is given to them. All rulers and local authorities should follow this farman and should not interfere in their religious and trade freedom. Because, Bohras are only traders and well-wishers of the empire.'
Bayram Khan 
 
Such good and kind deed of Moomineen to the emperor Humayu in the time of distress and the Royal Farman of the emperor reflect the greatness of Doat Kiram's guidance for their follower's, the Moomineen to the lofty human qualities and the policy of good relation with contemporary rulers. After ascending the throne of Dawat, Syedna Yusouf remained in his native city- Sidhpur. After some times, differences arose between Moomineen and Hindus of the city. Stubbornly, the Hindus boycotted Momineen in business and refused to allow them water from the public well. Stimulated by 'Gairat of Deen', Syedna developed a Mohallah (locality) of Moomineen, built twenty four shops and established a bazaar for Moomineen. He built a Masjid and dug a well by it. This courageous efforts of Syedna for the well- being of Moomineen failed Hindus in their evil-designs and compelled them to end their boycott.

After staying for five years in Al-Hind, Syedna Yusouf (R. A)did Hijrat to Yemen to fulfil the will of his predecessor, Syedna Mohammed (R. A). In Yemen, he remained for twenty years, guided Moomineen, collected the Kutub and Baraskat of Doat Kiram.and transferred them to Al-Hind. He regained some fortresses of Doat Kiram frm enemies.

In Y emen, Syedna Y usouf (R. A) was molested and harassed by Munafiqeen and enemies of Dawat. As a result of enemies' backbiting and intrigues, Aroom Pasha, the Turk deputy of Ottomans arrested Syedna and looted his home. He was freed from prison only after making promise to pay seven thousand Ibrahimi (local currency of that time). When the Sultan [Suleiman (1520-1566) ] came to know about this cruelty of his deputy, his summoned him and those involved in it. He punished them severely and issued a command that no one should molest Ismail Dai. Syedna Yusouf passed away in Yemen at Taibah. He appointed Syedna Jalal as his successor.
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During the period of Syedna Yusouf Najmuddin, Akber became the emperor of India in 1556 AD. Turks continued their attacks on East Europe and conquered Bosnia in 1563 AD. Queen Elizabeth 1 of England ascended the throne in 1558 (-1603). First War of Religion in France erupted between Catholic government and Protestant Huguenots.